Mitochondrial Nutrient Utilization Panel

MMA (Methylmalonic Acid)

• Assess whether vitamin B12 can actually be converted into cellular energy
  When B12 is insufficient or cannot be effectively activated by the body, MMA will increase, indicating that energy synthesis and nerve conduction efficiency are declining.
  ✔ Suitable for assessing: fatigue, brain fog, numbness in hands and feet, anemia, common risks for vegetarians.

5-MTHF (5-Methyltetrahydrofolate | Active folic acid)

• Tracking whether folic acid successfully enters the methylation and mitochondrial metabolism pathway
  This is the final form of folate that can be used by the body and is involved in DNA repair, detoxification, energy production and neural stability.
  ✔ Suitable for evaluation: preparation for childbirth, chronic fatigue, folic acid supplementation effects, and those with high metabolic stress.

UMFA (Unmetabolized Folic Acid)

• Check whether the wrong supplement type or excessive dosage may cause metabolic problems and potential risks
  High UMFA may reflect inefficient folate converting enzymes, which can interfere with immune, neural, and methylation pathways.
  ✔ Suitable for assessment: People who take folic acid supplements for a long time, people with MTHFR genotype, and people at risk of taking the wrong genotype.

Arginine

Amino acids that support NO production, blood circulation, and mitochondrial energy metabolism
Arginine levels that are too low can affect vascular elasticity and athletic performance, while high levels may be related to metabolic imbalance and urea cycle problems.
✔ Suitable for assessing: poor recovery from fatigue, blood pressure problems, poor exercise endurance or NO supplementation strategy planners.

TMAO（Trimethylamine-N-oxide）

Reflects cardiovascular risk substances produced by intestinal bacteria metabolizing red meat, choline and carnitine
When metabolic efficiency is poor or intestinal bacteria are unbalanced, elevated TMAO will aggravate mitochondrial oxidative stress, attack the vascular endothelium, and is highly correlated with the risk of atherosclerosis.
✔ Suitable for: People who eat high-protein diets, consume a lot of red meat, and have family history of cardiovascular disease

• I have already supplemented with folic acid, B12, B complex and other nutrients but I don't feel any obvious effects
• No matter how much sleep you get, you still feel tired, have difficulty concentrating, and your metabolism stagnates.
• Suspected mitochondrial dysfunction (eg, chronic fatigue, brain fog, poor exercise recovery)
• I want to figure out why I have no energy or stamina even though I take a lot of supplements.
• People who follow a high-protein/ketogenic/diet diet should be concerned about TMAO and arterial risk
• Design of personalized nutrition strategies and anti-aging supplementation plans